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  • Rabbit Anti-RAB38 Recombinant Antibody (D2V9Z)

Rabbit Anti-RAB38 Recombinant Antibody (D2V9Z) (CBMAB-R0839-CN)

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Basic Information

Host Animal
Rabbit
Clone
D2V9Z
Application
WB, IP
Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
More Infomation

Target

Full Name
RAB38, Member RAS Oncogene Family
Introduction
RAB38 (RAB38, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB38 include Frontotemporal Dementia and Hermansky-Pudlak Syndrome 5. Among its related pathways are Metabolism of proteins and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and protein complex binding. An important paralog of this gene is RAB32.
Entrez Gene ID
Human23682
Mouse72433
Rat252916
UniProt ID
HumanP57729
MouseQ8QZZ8
RatQ63483
Alternative Names
RAB38, Member RAS Oncogene Family; Melanoma Antigen NY-MEL-1; Rab-Related GTP-Binding Protein; Ras-Related Protein Rab-38; NY-MEL-1; RrGTPbp;
Function
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity).
Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211).
Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991).
In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)
Biological Process
Biological Process endosome to melanosome transportManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process melanosome assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process melanosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitochondrion organizationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process phagosome acidificationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process platelet dense granule organizationIEA:Ensembl
Biological Process positive regulation of phosphatidylcholine biosynthetic processIEA:Ensembl
Biological Process protein localization to membraneManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process protein transport1 PublicationNAS:UniProtKB
Biological Process small GTPase mediated signal transduction1 PublicationNAS:UniProtKB
Biological Process vesicle-mediated transportIEA:InterPro
Cellular Location
Cell membrane
Melanosome
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Melanosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991).
PTM
Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-RAB38 Recombinant Antibody (CBCNR-036) (CAT#: CBMAB-R0838-CN)

Mouse Anti-RAB38 Recombinant Antibody (7F1) (CAT#: CBMAB-R0836-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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