RAB5B
RAB5B (RAB5B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.
Full Name
RAB5B, Member RAS Oncogene Family
Function
Protein transport. Probably involved in vesicular traffic.
Biological Process
Biological Process antigen processing and presentationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endosome organizationIEA:Ensembl
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process plasma membrane to endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endosome organizationIEA:Ensembl
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process plasma membrane to endosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Early endosome membrane
Melanosome
Enriched in stage I melanosomes.
Early endosome membrane
Melanosome
Enriched in stage I melanosomes.
PTM
Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
(Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.
(Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.
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Anti-RAB5B antibodies
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Target: RAB5B
Sensitivity: 0.0071 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: RAB5B
Host: Mouse
Specificity: Human, Mouse
Clone: 16C220
Application*: E, WB
Target: RAB5B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 1615CT668.28.45
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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