RAB7B

RAB7B (RAB7B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Mitophagy - animal and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB7A.

Full Name

RAB7B, Member RAS Oncogene Family

Function

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

Biological Process

Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process endosome to lysosome transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process late endosome to Golgi transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of toll-like receptor 4 signaling pathwayISS:UniProtKB
Biological Process negative regulation of toll-like receptor 9 signaling pathwayISS:UniProtKB
Biological Process phagosome-lysosome fusionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW

Cellular Location

Late endosome
Lysosome
Golgi apparatus
Golgi apparatus, trans-Golgi network
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis.