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Mouse Anti-RAB7B Recombinant Antibody (3B3) (CBMAB-R0934-CN)

This product is a Mouse antibody that recognizes RAB7B. The antibody 3B3 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all RAB7B antibodies
Published Data
Fig.1 Lysates of monocyte-derived dendritic cells (MDDCs) were subjected to immunoprecipitation with an antibody against Rab7b or an isotype control (IgG2aK).
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Fig.2 Samples were subjected to affinity chromatography followed by western blot analysis using antibodies specific to GST and Rab7b.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B3
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa. 100-200 from human RAB7B (NP_796377) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
RAB7B, Member RAS Oncogene Family
Introduction
RAB7B (RAB7B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Mitophagy - animal and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB7A.
Entrez Gene ID
338382
UniProt ID
Q96AH8
Alternative Names
RAB7B, Member RAS Oncogene Family; Ras-Related Protein Rab-7b; Ras-Related Protein Rab-7; RAB7;
Function
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
Biological Process
Biological Process cellular response to interferon-gammaIEA:Ensembl
Biological Process endosome to lysosome transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process late endosome to Golgi transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of toll-like receptor 4 signaling pathwayISS:UniProtKB
Biological Process negative regulation of toll-like receptor 9 signaling pathwayISS:UniProtKB
Biological Process phagosome-lysosome fusionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportIEA:UniProtKB-KW
Cellular Location
Late endosome
Lysosome
Golgi apparatus
Golgi apparatus, trans-Golgi network
Cytoplasmic vesicle, phagosome
Cytoplasmic vesicle, phagosome membrane
Recruited to phagosomes containing S.aureus or M.tuberculosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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