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RAD18

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]

Full Name

RAD18, E3 Ubiquitin Protein Ligase

Function

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.

Biological Process

Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
DNA repair1 PublicationNAS:UniProtKB
Negative regulation of cell deathManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Postreplication repairManual Assertion Based On ExperimentIBA:GO_Central
Protein autoubiquitinationManual Assertion Based On ExperimentIDA:MGI
Protein monoubiquitinationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Associates with chromatin (PubMed:25931565).
Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077).
Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607).
Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).

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Anti-RAD18 antibodies

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Rabbit Anti-RAD18 Recombinant Antibody (D2B8) (CBMAB-R1052-CN)

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Target: RAD18

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D2B8

Application*: WB, IP, IF

Mouse Anti-RAD18 Recombinant Antibody (CBCNR-114) (CBMAB-R1051-CN)

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Target: RAD18

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Rat

Clone: CBCNR-114

Application*: IF, E, WB

Mouse Anti-RAD18 Recombinant Antibody (CBCNR-113) (CBMAB-R1050-CN)

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Target: RAD18

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Rat, Human

Clone: CBCNR-113

Application*: WB, P, F, CI, IF

Mouse Anti-RAD18 Recombinant Antibody (9C19) (CBMAB-R1048-CN)

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Target: RAD18

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9C19

Application*: WB

Mouse Anti-RAD18 Recombinant Antibody (3H7) (CBMAB-R1047-CN)

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Target: RAD18

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Rat

Clone: 3H7

Application*: E, IF, IH, WB

Mouse Anti-RAD18 Recombinant Antibody (2G8C10) (CBMAB-R1045-CN)

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Target: RAD18

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2G8C10

Application*: E, WB, F

Mouse Anti-RAD18 Recombinant Antibody (79B1048.1) (CBMAB-R0049-CN)

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Target: RAD18

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 79B1048.1

Application*: WB

Human RAD18 ELISA Kit (V2LY-0626-LY4521)

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Target: RAD18

Sensitivity: 0.005 ng/mL

Detection Range: 0.01-2 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Mouse Anti-RAD18 Recombinant Antibody (CBT2411) (V2LY-0625-LY346)

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Target: RAD18

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2411

Application*: F

Mouse Anti-RAD18 Recombinant Antibody (CBT3995) (V2LY-0625-LY274)

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Target: RAD18

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3995

Application*: F

RAD18 Matched Antibody Pair (960) (APMAB-960LY)

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Target: RAD18

Specificity: Human

Mouse Anti-RAD18 Antibody (11BA3) (CBMAB-1531CQ)

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Target: RAD18

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 11BA3

Application*: E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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