RAD18

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
Full Name
RAD18, E3 Ubiquitin Protein Ligase
Function
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.
Biological Process
Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
DNA repair1 PublicationNAS:UniProtKB
Negative regulation of cell deathManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Postreplication repairManual Assertion Based On ExperimentIBA:GO_Central
Protein autoubiquitinationManual Assertion Based On ExperimentIDA:MGI
Protein monoubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Associates with chromatin (PubMed:25931565).
Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077).
Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607).
Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565).
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Anti-RAD18 antibodies

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Rabbit Anti-RAD18 Recombinant Antibody (D2B8) (CBMAB-R1052-CN)

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Target: RAD18
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D2B8
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-RAD18 Recombinant Antibody (CBCNR-114) (CBMAB-R1051-CN)

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Target: RAD18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: CBCNR-114
Application*: IF, E, WB
Datasheet SDS

Mouse Anti-RAD18 Recombinant Antibody (CBCNR-113) (CBMAB-R1050-CN)

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Target: RAD18
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat, Human
Clone: CBCNR-113
Application*: WB, P, F, CI, IF
Datasheet SDS

Mouse Anti-RAD18 Recombinant Antibody (9C19) (CBMAB-R1048-CN)

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Target: RAD18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9C19
Application*: WB
Datasheet SDS

Mouse Anti-RAD18 Recombinant Antibody (3H7) (CBMAB-R1047-CN)

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Target: RAD18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat
Clone: 3H7
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-RAD18 Recombinant Antibody (2G8C10) (CBMAB-R1045-CN)

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Target: RAD18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G8C10
Application*: E, WB, F
Datasheet SDS

Mouse Anti-RAD18 Recombinant Antibody (79B1048.1) (CBMAB-R0049-CN)

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Target: RAD18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 79B1048.1
Application*: WB
Datasheet SDS

Mouse Anti-RAD18 Recombinant Antibody (CBT2411) (V2LY-0625-LY346)

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Target: RAD18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2411
Application*: F
Datasheet SDS

Mouse Anti-RAD18 Recombinant Antibody (CBT3995) (V2LY-0625-LY274)

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Target: RAD18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3995
Application*: F
Datasheet SDS

RAD18 Matched Antibody Pair (960) (APMAB-960LY)

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Target: RAD18
Specificity: Human
Datasheet SDS

Mouse Anti-RAD18 Antibody (11BA3) (CBMAB-1531CQ)

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Target: RAD18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11BA3
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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