RALGAPA1

This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016]
Full Name
Ral GTPase Activating Protein Catalytic Alpha Subunit 1
Function
Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
Biological Process
Biological Process activation of GTPase activityISS:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Cellular Location
Cytoplasm
Nucleus
Translocated to the nucleus, when associated with TCF3/E12.
Involvement in disease
Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation (NEDHRIT):
An autosomal recessive disorder characterized by profound neurodevelopmental disability, muscular hypotonia, feeding abnormalities, recurrent fever episodes, infantile spasms, and moderate dysmorphic facial features. Brain imaging shows thin corpus or dysplastic corpus callosum, and additional unspecific abnormalities including gray matter heterotopias, ectopic posterior pituitary, signal abnormalities in basal ganglia, and stratum subependymale.
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Anti-RALGAPA1 antibodies

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Mouse Anti-RALGAPA1 Recombinant Antibody (CBLG1-2430) (CBMAB-G6528-LY)

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Target: RALGAPA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2430
Application*: WB
Datasheet SDS

Rabbit Anti-RALGAPA1 Recombinant Antibody (CBLG1-3099) (CBMAB-G6526-LY)

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Target: RALGAPA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3099
Application*: WB
Datasheet SDS

Mouse Anti-RALGAPA1 Recombinant Antibody (8C170) (CBMAB-G6525-LY)

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Target: RALGAPA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8C170
Application*: DB, WB
Datasheet SDS

Mouse Anti-RALGAPA1 Recombinant Antibody (2382C1a) (CBMAB-G1171-LY)

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Target: RALGAPA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2382C1a
Application*: DB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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