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Mouse Anti-RALGAPA1 Recombinant Antibody (8C170) (CBMAB-G6525-LY)

This product is antibody recognizes RALGAPA1. The antibody 8C170 immunoassay techniques such as: Dot Blot, WB.
See all RALGAPA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8C170
Antibody Isotype
IgG1
Application
Dot Blot, WB

Basic Information

Immunogen
Partial sequence of recombinant full-length protein to human GTPase Activating Rap/RanGAP Domain-like 1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA
Concentration
0.1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ral GTPase Activating Protein Catalytic Alpha Subunit 1
Introduction
This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016]
Entrez Gene ID
253959
UniProt ID
Q6GYQ0
Alternative Names
Ral GTPase Activating Protein Catalytic Alpha Subunit 1; Tuberin-Like Protein 1; GTPase Activating Rap/RanGAP Domain-Like 1; GAP-Related Interacting Protein To E12; GARNL1; TULIP1; GRIPE; P240;
Function
Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
Biological Process
Biological Process activation of GTPase activityISS:UniProtKB
Biological Process regulation of small GTPase mediated signal transductionIEA:InterPro
Cellular Location
Cytoplasm
Nucleus
Translocated to the nucleus, when associated with TCF3/E12.
Involvement in disease
Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation (NEDHRIT):
An autosomal recessive disorder characterized by profound neurodevelopmental disability, muscular hypotonia, feeding abnormalities, recurrent fever episodes, infantile spasms, and moderate dysmorphic facial features. Brain imaging shows thin corpus or dysplastic corpus callosum, and additional unspecific abnormalities including gray matter heterotopias, ectopic posterior pituitary, signal abnormalities in basal ganglia, and stratum subependymale.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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