RAMP2

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq]

Full Name

receptor (G protein-coupled) activity modifying protein 2

Function

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Biological Process

Biological Process adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process adherens junction assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process adrenomedullin receptor signaling pathwayManual Assertion Based On ExperimentIPI:UniProtKB
Biological Process amylin receptor signaling pathwayManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process basement membrane assemblyISS:UniProtKB
Biological Process bicellular tight junction assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to vascular endothelial growth factor stimulusISS:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heart developmentISS:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process negative regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of vascular permeabilityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of angiogenesisISS:UniProtKB
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of vasculogenesisIEA:Ensembl
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process receptor internalizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of blood pressureISS:UniProtKB
Biological Process regulation of G protein-coupled receptor signaling pathwayIEA:InterPro
Biological Process sprouting angiogenesisISS:UniProtKB
Biological Process vascular associated smooth muscle cell developmentISS:UniProtKB
Biological Process vasculogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 43-145
Helical: 146-166
Cytoplasmic: 167-175