RAP2B

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq]
Full Name
RAP2B, member of RAS oncogene family
Function
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
Biological Process
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process platelet activationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process platelet aggregationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein autophosphorylationIEA:Ensembl
Biological Process Rap protein signal transductionISS:UniProtKB
Biological Process regulation of protein tyrosine kinase activityISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Recycling endosome membrane
Associated with red blood cells-released vesicles.
PTM
Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK.
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Anti-RAP2B antibodies

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Mouse Anti-RAP2B Recombinant Antibody (CBCNR-202) (CBMAB-R1334-CN)

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Target: RAP2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBCNR-202
Application*: E, WB
Datasheet SDS

Mouse Anti-RAP2B Recombinant Antibody (CBCNR-201) (CBMAB-R1333-CN)

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Target: RAP2B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Human
Clone: CBCNR-201
Application*: WB, P, F, IF
Datasheet SDS

Mouse Anti-RAP2B Recombinant Antibody (AT62D9) (CBMAB-R1331-CN)

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Target: RAP2B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AT62D9
Application*: WB
Datasheet SDS

Mouse Anti-RAP2B Recombinant Antibody (9H175) (CBMAB-R1330-CN)

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Target: RAP2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9H175
Application*: WB
Datasheet SDS

Mouse Anti-RAP2B Recombinant Antibody (4F12-3C6) (CBMAB-R1329-CN)

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Target: RAP2B
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4F12-3C6
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-RAP2B Recombinant Antibody (455517) (CBMAB-R1328-CN)

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Target: RAP2B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 455517
Application*: WB
Datasheet SDS

Mouse Anti-RAP2B Recombinant Antibody (15B57) (CBMAB-R1327-CN)

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Target: RAP2B
Host: Mouse
Specificity: Human
Clone: 15B57
Application*: E, WB
Datasheet SDS

Mouse Anti-RAP2B Recombinant Antibody (62D9) (CBMAB-R0109-CN)

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Target: RAP2B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 62D9
Application*: WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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