Mouse Anti-RAP2B Recombinant Antibody (455517) (CBMAB-R1328-CN)

Name: Mouse Anti-RAP2B Recombinant Antibody (455517)
SKU: CBMAB-R1328-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

455517

Application

Immunogen

E. coli-derived recombinant human Rap2B, Met1-Leu183, Accession # P61225

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

LYOPH

Buffer

PBS, Trehalose

Concentration

LYOPH

More Infomation

Target

Full Name

RAP2B, member of RAS oncogene family

Introduction

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

Entrez Gene ID

5912

UniProt ID

P61225

Alternative Names

RAP2B, Member Of RAS Oncogene Family; Ras Family Small GTP Binding Protein RAP2B; Ras-Related Protein RAP-2B; Small GTP Binding Protein;

Function

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.

Biological Process

Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process platelet activationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process platelet aggregationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein autophosphorylationIEA:Ensembl
Biological Process Rap protein signal transductionISS:UniProtKB
Biological Process regulation of protein tyrosine kinase activityISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Recycling endosome membrane
Associated with red blood cells-released vesicles.

PTM

Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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