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Mouse Anti-RAP2B Recombinant Antibody (62D9) (CBMAB-R0109-CN)

This product is a Mouse antibody that recognizes RAP2B. The antibody 62D9 can be used for immunoassay techniques such as: WB, ELISA.
See all RAP2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
62D9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
Recombinant human RAP2B (aa. 1-183) purified from E. coli
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
RAP2B, member of RAS oncogene family
Introduction
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5912
UniProt ID
P61225
Alternative Names
RAP2B, Member Of RAS Oncogene Family; Ras Family Small GTP Binding Protein RAP2B; Ras-Related Protein RAP-2B; Small GTP Binding Protein;
Function
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
Biological Process
Biological Process negative regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process platelet activationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process platelet aggregationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein autophosphorylationIEA:Ensembl
Biological Process Rap protein signal transductionISS:UniProtKB
Biological Process regulation of protein tyrosine kinase activityISS:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Recycling endosome membrane
Associated with red blood cells-released vesicles.
PTM
Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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