RARS

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]

Full Name

Arginyl-TRNA Synthetase

Function

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775).
Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684).

Biological Process

Biological Process arginyl-tRNA aminoacylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process tRNA aminoacylation for protein translationTAS:Reactome

Cellular Location

Cytoplasm
Cytoplasm, cytosol

Involvement in disease

Leukodystrophy, hypomyelinating, 9 (HLD9):
An autosomal recessive neurodegenerative disorder characterized by delayed psychomotor development, severe spasticity, nystagmus, and ataxia associated with diffuse hypomyelination apparent on brain MRI.

Anti-RARS antibodies

Mouse Anti-RARS Recombinant Antibody (CBYC-A1033) (CBMAB-A4699-YC)

Datasheet

SDS

Target: RARS

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYC-A1033

Application*: WB, IC, P, C, E

Mouse Anti-RARS Recombinant Antibody (CBYC-A1032) (CBMAB-A4698-YC)

Datasheet

SDS

Target: RARS

Host: Mouse

Antibody Isotype: IgM

Specificity: Human

Clone: CBYC-A1032

Application*: WB, E

Mouse Anti-RARS Recombinant Antibody (V2-82938) (CBMAB-R1446-CN)

Datasheet

SDS

Target: RARS

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: V2-82938

Application*: E, IH, WB

RARS Matched Antibody Pair (967) (APMAB-967LY)

Datasheet

SDS

Target: RARS

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)