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Mouse Anti-RARS Recombinant Antibody (V2-82938) (CBMAB-R1446-CN)

This product is a Mouse antibody that recognizes RARS. The antibody 1A2 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all RARS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-82938
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Full length recombinant corresponding to human RARS, aa. 1-661 (H00528) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Arginyl-TRNA Synthetase
Introduction
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5917
UniProt ID
P54136
Alternative Names
Arginyl-TRNA Synthetase; Arginine TRNA Ligase 1, Cytoplasmic; EC 6.1.1.19; ArgRS; Arginyl-TRNA Synthetase, Cytoplasmic; Arginine--TRNA Ligase, Cytoplasmic; DALRD1; HLD9;
Function
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775).
Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684).
Biological Process
Biological Process arginyl-tRNA aminoacylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process tRNA aminoacylation for protein translationTAS:Reactome
Cellular Location
Cytoplasm
Cytoplasm, cytosol
Involvement in disease
Leukodystrophy, hypomyelinating, 9 (HLD9):
An autosomal recessive neurodegenerative disorder characterized by delayed psychomotor development, severe spasticity, nystagmus, and ataxia associated with diffuse hypomyelination apparent on brain MRI.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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