RDH11

RHD11, a member of the short-chain dehydrogenase/reductase (SDR) superfamily of oxidoreductases, is expressed at high levels in prostate epithelium, and its expression is regulated by androgens.[supplied by OMIM

Full Name

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

Function

Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696).
Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448).
Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956).

Biological Process

Biological Process adaptation of rhodopsin mediated signalingIEA:Ensembl
Biological Process cellular detoxification of aldehydeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retinal metabolic processManual Assertion Based On ExperimentIDA:MGI
Biological Process retinoid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retinol metabolic processISS:UniProtKB
Biological Process visual perceptionIEA:Ensembl

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Retinal dystrophy, juvenile cataracts, and short stature syndrome (RDJCSS):
A disorder characterized by retinal dystrophy resulting in progressive decrease in visual acuity and difficulties with night vision in the first decade of life, development of juvenile cataracts, facial dysmorphism, psychomotor developmental delays, learning disabilities and short stature. Ophthalmological findings include salt-and-pepper retinopathy, attenuation of the arterioles, generalized rod-cone dysfunction, mottled macula at an early age, and peripapillary sparing of the retinal pigment epithelium.

Topology

Helical: 1-21
Cytoplasmic: 22-318

PTM

Not glycosylated.