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Mouse Anti-RDH11 Recombinant Antibody (CBCNR-364) (CBMAB-R1981-CN)

This product is a Mouse antibody that recognizes RDH11. The antibody CBCNR-364 can be used for immunoassay techniques such as: ELISA, WB.
See all RDH11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-364
Antibody Isotype
IgG1, λ
Application
ELISA, WB

Basic Information

Immunogen
RDH11 (H00112, aa. 24-318) full-length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
Introduction
The protein encoded by this gene is an NADPH-dependent retinal reductase and a short-chain dehydrogenase/reductase. The encoded protein has no steroid dehydrogenase activity. [provided by RefSeq, Nov 2011]
Entrez Gene ID
51109
UniProt ID
Q8TC12
Alternative Names
Retinol Dehydrogenase 11 (All-Trans/9-Cis/11-Cis); Androgen-Regulated Short-Chain Dehydrogenase/Reductase 1; Short Chain Dehydrogenase/Reductase Family 7C, Member 1; HCV Core-Binding Protein HCBP12; Retinal Reductase 1; ARSDR1; SDR7C1; RALR1; PSDR1; Short Chain Dehydrogenase/Reductase Family 7C Member 1; Retinol Dehydrogenase 11 (All-Trans And 9-Cis);
Function
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696).
Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448).
Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956).
Biological Process
Biological Process adaptation of rhodopsin mediated signalingIEA:Ensembl
Biological Process cellular detoxification of aldehydeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retinal metabolic processManual Assertion Based On ExperimentIDA:MGI
Biological Process retinoid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process retinol metabolic processISS:UniProtKB
Biological Process visual perceptionIEA:Ensembl
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Retinal dystrophy, juvenile cataracts, and short stature syndrome (RDJCSS):
A disorder characterized by retinal dystrophy resulting in progressive decrease in visual acuity and difficulties with night vision in the first decade of life, development of juvenile cataracts, facial dysmorphism, psychomotor developmental delays, learning disabilities and short stature. Ophthalmological findings include salt-and-pepper retinopathy, attenuation of the arterioles, generalized rod-cone dysfunction, mottled macula at an early age, and peripapillary sparing of the retinal pigment epithelium.
Topology
Helical: 1-21
Cytoplasmic: 22-318
PTM
Not glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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