REG3G

REG3G is a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. X is an antimicrobial lectin with activity against Gram-posi
Full Name
Regenerating Family Member 3 Gamma
Function
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cytolysis by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumISS:UniProtKB
Biological Process MyD88-dependent toll-like receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of keratinocyte differentiationISS:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of keratinocyte proliferationISS:UniProtKB
Biological Process positive regulation of wound healingISS:UniProtKB
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Cytoplasm
PTM
Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
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Anti-REG3G antibodies

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Rabbit Anti-REG3G Recombinant Antibody (002) (CBMAB-R2075-CN)

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Target: REG3G
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 002
Application*: E
Datasheet SDS

Rabbit Anti-REG3G Recombinant Antibody (CBFYH-2729) (CBMAB-H3788-FY)

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Target: REG3G
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2729
Application*: E, WB
Datasheet SDS

Mouse Anti-REG3G Antibody (4G3) (CBMAB-0074-YC)

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Target: REG3G
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4G3
Application*: WB
Datasheet SDS

Mouse Anti-REG3G Antibody (4B11) (CBMAB-0073-YC)

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Target: REG3G
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4B11
Application*: WB
Datasheet SDS

Mouse Anti-REG3G Antibody (4A5) (CBMAB-0072-YC)

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Target: REG3G
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4A5
Application*: WB
Datasheet SDS

Mouse Anti-REG3G Antibody (3E1) (CBMAB-0071-YC)

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Target: REG3G
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3E1
Application*: WB
Datasheet SDS

Mouse Anti-REG3G Antibody (3A3) (CBMAB-0070-YC)

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Target: REG3G
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3A3
Application*: WB
Datasheet SDS

Mouse Anti-REG3G Antibody (2B6) (CBMAB-0069-YC)

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Target: REG3G
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2B6
Application*: WB
Datasheet SDS

Mouse Anti-REG3G Antibody (1E6) (CBMAB-0068-YC)

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Target: REG3G
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1E6
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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