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REG3G

REG3G is a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. X is an antimicrobial lectin with activity against Gram-posi
Full Name
Regenerating Family Member 3 Gamma
Function
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cytolysis by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumISS:UniProtKB
Biological Process MyD88-dependent toll-like receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of keratinocyte differentiationISS:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of keratinocyte proliferationISS:UniProtKB
Biological Process positive regulation of wound healingISS:UniProtKB
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Cytoplasm
PTM
Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.

Anti-REG3G antibodies

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Target: REG3G
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 002
Application*: E
Target: REG3G
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2729
Application*: E, WB
Target: REG3G
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4G3
Application*: WB
Target: REG3G
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4B11
Application*: WB
Target: REG3G
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4A5
Application*: WB
Target: REG3G
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3E1
Application*: WB
Target: REG3G
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3A3
Application*: WB
Target: REG3G
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2B6
Application*: WB
Target: REG3G
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1E6
Application*: WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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