Mouse Anti-REG3G Antibody (2B6) (CBMAB-0069-YC)

Name: Mouse Anti-REG3G Antibody (2B6)
SKU: CBMAB-0069-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

2B6

Application

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Regenerating Family Member 3 Gamma

Introduction

Regenerating islet-derived 3 gamma (REG3G) is a member of the secreted Reg superfamily and contains one typical C-type lectin domain. REG3G is expressed weakly in pancreas, strongly in intestinal tract, but not in hyperplastic islets REG3G might be a stress protein involved in the control of bacterial proliferation. It binds to Gram-positive bacteria surface peptidoglycan layer, and serves as one of several antimicrobial peptides produced by paneth cells via stimulation of toll-like receptors (TLRs) by pathogen-associated molecular patterns (PAMPs).

Entrez Gene ID

130120

UniProt ID

Q6UW15

Alternative Names

PAP1B; PAPIB; PAP IB; PAP-1B; UNQ429; LPPM429; REG III; REG-III

Function

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.

Biological Process

Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cytolysis by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumISS:UniProtKB
Biological Process MyD88-dependent toll-like receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of keratinocyte differentiationISS:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of keratinocyte proliferationISS:UniProtKB
Biological Process positive regulation of wound healingISS:UniProtKB
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted
Cytoplasm

PTM

Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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