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Rabbit Anti-REG3G Recombinant Antibody (002) (CBMAB-R2075-CN)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
002
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human REG3G protein
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Regenerating Family Member 3 Gamma
Introduction
This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]
Entrez Gene ID
130120
UniProt ID
Q6UW15
Alternative Names
Regenerating Family Member 3 Gamma; Regenerating Islet-Derived Protein III-Gamma; Regenerating Islet-Derived 3 Gamma; Pancreatitis-Associated Protein 1B; Pancreatitis-Associated Protein IB; Reg III-Gamma; REG-3-Gamma; REG III; PAP IB;
Function
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cytolysis by host of symbiont cellsManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumISS:UniProtKB
Biological Process MyD88-dependent toll-like receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of keratinocyte differentiationISS:UniProtKB
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of keratinocyte proliferationISS:UniProtKB
Biological Process positive regulation of wound healingISS:UniProtKB
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Cytoplasm
PTM
Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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