RGS4

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Regulator Of G Protein Signaling 4

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

Biological Process brain developmentIEA:Ensembl
Biological Process dorsal root ganglion developmentIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of cell growth involved in cardiac muscle cell developmentIEA:Ensembl
Biological Process negative regulation of dopamine receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of glycine import across plasma membraneIEA:Ensembl
Biological Process negative regulation of potassium ion transmembrane transportIEA:Ensembl
Biological Process positive regulation of excitatory postsynaptic potentialIEA:Ensembl
Biological Process positive regulation of GTPase activityIEA:Ensembl
Biological Process positive regulation of heart rateIEA:Ensembl
Biological Process regulation of actin filament organizationIEA:Ensembl
Biological Process regulation of calcium ion transportIEA:Ensembl
Biological Process regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process response to amphetamineIEA:Ensembl
Biological Process response to cocaineIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process response to morphineIEA:Ensembl

cytoplasm
cytosol
nucleus
plasma membrane
protein-containing complex

Schizophrenia (SCZD):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

Palmitoylated on Cys-2 and/or Cys-12.
Phosphorylated by cyclic GMP-dependent protein kinase.