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RLBP1

The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq]

Full Name

retinaldehyde binding protein 1

Function

Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.

Biological Process

Biological Process response to stimulusIEA:UniProtKB-KW
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process vitamin A metabolic processManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm

Involvement in disease

Bothnia retinal dystrophy (BRD):
A type of retinitis punctata albescens. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration.
Rod-cone dystrophy Newfoundland (NFRCD):
A rod-cone dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss.
Retinitis punctata albescens (RPA):
A form of fleck retina disease characterized by aggregation of white flecks posteriorly in the retina, causing night blindness and delayed dark adaptation. It differs from fundus albipunctatus in being progressive and evolving to generalized atrophy of the retina.

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Anti-RLBP1 antibodies

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Mouse Anti-RLBP1 Recombinant Antibody (CBWJC-4378) (CBMAB-C5759WJ)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBWJC-4378

Application*: WB, IP, IF, E

Mouse Anti-RLBP1 Recombinant Antibody (CBFYC-3081) (CBMAB-C3158-FY)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-3081

Application*: WB, F, IH, P

Mouse Anti-RLBP1 Recombinant Antibody (CBFYC-3080) (CBMAB-C3157-FY)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse, Rat

Clone: CBFYC-3080

Application*: WB, IP

Mouse Anti-RLBP1 Monoclonal Antibody (B2) (CBMAB-0972-YC)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat, Cattle, Pig, Monkey

Clone: B2

Application*: IC, IF, C, P, WB

Mouse Anti-RLBP1 Recombinant Antibody (CBCNC-698) (CBMAB-C4218-CN)

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Target: RLBP1

Host: Mouse

Specificity: Human

Clone: CBCNC-698

Application*: WB, ICC, P, IH-F, E

Mouse Anti-RLBP1 Recombinant Antibody (5G2) (CBMAB-R2798-CN)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5G2

Application*: WB

Mouse Anti-RLBP1 Recombinant Antibody (4H5) (CBMAB-R2797-CN)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4H5

Application*: E, IF, WB

Mouse Anti-RLBP1 Recombinant Antibody (2A5) (CBMAB-R2796-CN)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A5

Application*: WB

Mouse Anti-RLBP1 Recombinant Antibody (1H5) (CBMAB-R2794-CN)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1H5

Application*: WB

Mouse Anti-RLBP1 Recombinant Antibody (1G6) (CBMAB-R2793-CN)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1G6

Application*: WB, IH, F

Mouse Anti-RLBP1 Recombinant Antibody (1F5) (CBMAB-R2792-CN)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1F5

Application*: WB

Mouse Anti-RLBP1 Recombinant Antibody (1B4) (CBMAB-R2791-CN)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1B4

Application*: WB

Mouse Anti-RLBP1 Recombinant Antibody (13A14) (CBMAB-R2790-CN)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: 13A14

Application*: IP, WB

Mouse Anti-RLBP1 Recombinant Antibody (10A10) (CBMAB-R2789-CN)

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Target: RLBP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 10A10

Application*: WB, IP

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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