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Mouse Anti-RLBP1 Recombinant Antibody (10A10) (CBMAB-R2789-CN)

This product is a Mouse antibody that recognizes RLBP1. The antibody 10A10 can be used for immunoassay techniques such as: WB, IP.
See all RLBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10A10
Antibody Isotype
IgG1, κ
Application
WB, IP

Basic Information

Immunogen
A recombinant human protein purified from E.coli (His-CRALBP)
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
retinaldehyde binding protein 1
Introduction
The protein encoded by this gene is a 36-kD water-soluble protein which carries 11-cis-retinaldehyde or 11-cis-retinal as physiologic ligands. It may be a functional component of the visual cycle. Mutations of this gene have been associated with severe rod-cone dystrophy, Bothnia dystrophy (nonsyndromic autosomal recessive retinitis pigmentosa) and retinitis punctata albescens. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6017
UniProt ID
P12271
Alternative Names
Retinaldehyde Binding Protein 1; Cellular Retinaldehyde-Binding Protein; Retinaldehyde-Binding Protein 1; CRALBP; Cellular Retinaldehyde-Binding Protein-1;
Function
Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
Biological Process
Biological Process response to stimulusIEA:UniProtKB-KW
Biological Process visual perceptionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process vitamin A metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Involvement in disease
Bothnia retinal dystrophy (BRD):
A type of retinitis punctata albescens. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration.
Rod-cone dystrophy Newfoundland (NFRCD):
A rod-cone dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss.
Retinitis punctata albescens (RPA):
A form of fleck retina disease characterized by aggregation of white flecks posteriorly in the retina, causing night blindness and delayed dark adaptation. It differs from fundus albipunctatus in being progressive and evolving to generalized atrophy of the retina.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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