RLN2

This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016]

Full Name

Relaxin 2

Function

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.

Biological Process

Biological Process female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:CACAO
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIDA:CACAO
Biological Process regulation of catalytic activityManual Assertion Based On ExperimentIDA:CACAO

Cellular Location

Secreted