RMND5A

RMND5A (Required For Meiotic Nuclear Division 5 Homolog A) is a Protein Coding gene. Diseases associated with RMND5A include Meningoencephalocele. An important paralog of this gene is RMND5B.
Full Name
Required For Meiotic Nuclear Division 5 Homolog A
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972).
Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972).
The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).
Biological Process
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationISS:UniProtKB
Cellular Location
Nucleus, nucleoplasm
Cytoplasm
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Anti-RMND5A antibodies

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Mouse Anti-RMND5A Recombinant Antibody (3D1) (CBMAB-R2832-CN)

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Target: RMND5A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3D1
Application*: WB
Datasheet SDS

Mouse Anti-RMND5A Recombinant Antibody (2C8) (CBMAB-R2831-CN)

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Target: RMND5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C8
Application*: WB
Datasheet SDS

Mouse Anti-RMND5A Recombinant Antibody (2C6) (CBMAB-R2830-CN)

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Target: RMND5A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2C6
Application*: WB
Datasheet SDS

Mouse Anti-RMND5A Recombinant Antibody (1B7) (CBMAB-R2829-CN)

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Target: RMND5A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B7
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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