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RMND5A

RMND5A (Required For Meiotic Nuclear Division 5 Homolog A) is a Protein Coding gene. Diseases associated with RMND5A include Meningoencephalocele. An important paralog of this gene is RMND5B.

Full Name

Required For Meiotic Nuclear Division 5 Homolog A

Function

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972).
Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972).
The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).

Biological Process

Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationISS:UniProtKB

Cellular Location

Nucleus, nucleoplasm
Cytoplasm

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Anti-RMND5A antibodies

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Mouse Anti-RMND5A Recombinant Antibody (3D1) (CBMAB-R2832-CN)

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Target: RMND5A

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 3D1

Application*: WB

Mouse Anti-RMND5A Recombinant Antibody (2C8) (CBMAB-R2831-CN)

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Target: RMND5A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2C8

Application*: WB

Mouse Anti-RMND5A Recombinant Antibody (2C6) (CBMAB-R2830-CN)

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Target: RMND5A

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2C6

Application*: WB

Mouse Anti-RMND5A Recombinant Antibody (1B7) (CBMAB-R2829-CN)

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Target: RMND5A

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1B7

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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