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Mouse Anti-RMND5A Recombinant Antibody (1B7) (CBMAB-R2829-CN)

This product is a Mouse antibody that recognizes RMND5A. The antibody 1B7 can be used for immunoassay techniques such as: WB.
See all RMND5A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B7
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to aa. 1-249 of human RMND5A (NP_073617) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
Required For Meiotic Nuclear Division 5 Homolog A
Introduction
RMND5A (Required For Meiotic Nuclear Division 5 Homolog A) is a Protein Coding gene. Diseases associated with RMND5A include Meningoencephalocele. An important paralog of this gene is RMND5B.
Entrez Gene ID
64795
UniProt ID
Q9H871
Alternative Names
Required For Meiotic Nuclear Division 5 Homolog A; 44-KD Protein Coding For CTLH Motif; GID Complex Subunit 2 Homolog A; Required For Meiotic Nuclear Division 5 Homolog A (S. Cerevisiae); C-Terminal To LisH Motif, 44 KDa; Protein RMD5 Homolog A;
Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972).
Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972).
The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).
Biological Process
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationISS:UniProtKB
Cellular Location
Nucleus, nucleoplasm
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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