RSPH1

RSPH1 is a male meiotic metaphase chromosome-associated acidic protein. RSPH1 is expressed in tissues with motile cilia or flagella, including the trachea, lungs, airway brushings, and testes. Mutations in RSPH1 result in primary ciliary dyskinesia-24.

Full Name

Radial Spoke Head 1 Homolog

Function

May play an important role in male meiosis (By similarity).
It is necessary for proper building of the axonemal central pair and radial spokes.

Biological Process

Biological Process axoneme assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process meiotic cell cycleIEA:UniProtKB-KW
Biological Process spermatid developmentManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cell projection, cilium
Cytoplasmic in late spermatocytes, secondary spermatocytes and round spermatids. Gathered around metaphase chromosomes during meiotic divisions (By similarity).

Involvement in disease

Ciliary dyskinesia, primary, 24 (CILD24):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Situs inversus is not observed in CILD24 patients.

Anti-RSPH1 antibodies

Mouse Anti-RSPH1 Recombinant Antibody (CBYJT-1647) (CBMAB-T0693-YJ)

Datasheet

SDS

Target: RSPH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-1647

Application*: E, WB

Mouse Anti-RSPH1 Recombinant Antibody (3G6) (CBMAB-A9572-LY)

Datasheet

SDS

Target: RSPH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G6

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)