RTF2

RTF2 (Replication Termination Factor 2) is a Protein Coding gene.

Replication Termination Factor 2

Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612).

Biological Process cellular response to hydroxyureaManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic DNA replication terminationIEA:InterPro
Biological Process regulation of DNA stabilityManual Assertion Based On ExperimentIMP:UniProtKB

Chromosome
Localizes at the replication fork.

Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability.