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Mouse Anti-RTF2 Recombinant Antibody (CBYY-C3250) (CBMAB-C4693-YY)

This product is mouse antibody that recognizes RTF2. The antibody CBYY-C3250 can be used for immunoassay techniques such as: WB, IF
See all RTF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C3250
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Replication Termination Factor 2
Entrez Gene ID
51507
UniProt ID
Q9BY42
Alternative Names
Cytochrome C Oxidase Subunit 6A1; Cytochrome C Oxidase Subunit VIa Polypeptide 1; Cytochrome C Oxidase Polypeptide VIa-Liver; Cytochrome C Oxidase Subunit VIA-Liver; COX VIa-L; COX6AL;
Function
Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612).
Biological Process
Biological Process cellular response to hydroxyureaManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic DNA replication terminationIEA:InterPro
Biological Process regulation of DNA stabilityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Chromosome
Localizes at the replication fork.
PTM
Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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