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Mouse Anti-RTF2 Recombinant Antibody (1E8) (CBMAB-C3988-LY)

This product is antibody recognizes RTF2. The antibody 1E8 immunoassay techniques such as: WB, FC, IHC, ICC/IF, IHC-P.
See all RTF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E8
Antibody Isotype
IgG2b
Application
WB, FC, IHC, ICC/IF, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human C20orf43 (NP_057491) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Replication Termination Factor 2
Introduction
RTF2 (Replication Termination Factor 2) is a Protein Coding gene.
Entrez Gene ID
51507
UniProt ID
Q9BY42
Alternative Names
Replication Termination Factor 2; Replication Termination Factor 2 Domain Containing 1; RTFDC1; Replication Termination Factor 2 Domain-Containing Protein 1; C20orf43; Chromosome 20 Open Reading Frame 43;
Function
Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612).
Biological Process
Biological Process cellular response to hydroxyureaManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic DNA replication terminationIEA:InterPro
Biological Process regulation of DNA stabilityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Chromosome
Localizes at the replication fork.
PTM
Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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