S. pombe Cig2

Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle.

Full Name

G1/S-specific B-type cyclin Cig2

Function

Biological Process

Biological Process cell divisionIEA:UniProtKB-KW
Biological Process DNA recombinationManual Assertion Based On ExperimentIMP:PomBase
Biological Process G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:PomBase
Biological Process G2/M transition of mitotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitotic cell cycle phase transitionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mitotic G1 cell size control checkpoint signalingManual Assertion Based On ExperimentIGI:PomBase
Biological Process negative regulation of conjugation with cellular fusionManual Assertion Based On ExperimentIMP:PomBase
Biological Process positive regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:PomBase
Biological Process regulation of cell cycle switching, mitotic to meiotic cell cycleManual Assertion Based On ExperimentIMP:PomBase
Biological Process regulation of cyclin-dependent protein serine/threonine kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process traversing start control point of mitotic cell cycleManual Assertion Based On ExperimentIGI:PomBase

Cellular Location

Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body

PTM

Phosphorylated.