SCTR

The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq]

Full Name

secretin receptor

Function

Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:7612008, PubMed:25332973).
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
Upon binding to secretin, regulates the pH of the duodenum by 1 inhibiting the secretion of gastric acid from the parietal cells of the stomach and 2 stimulating the production of bicarbonate (NaHCO3) from the ductal cells of the pancreas (By similarity).
In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).

Biological Process

Biological Process adenylate cyclase-modulating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell surface receptor signaling pathwayIEA:InterPro
Biological Process cellular water homeostasisISS:UniProtKB
Biological Process diet induced thermogenesisISS:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:GO_Central
Biological Process positive regulation of cAMP-mediated signalingISS:UniProtKB
Biological Process regulation of appetiteISS:UniProtKB
Biological Process regulation of synaptic plasticityISS:UniProtKB
Biological Process response to nutrient levelsISS:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 23-143
Helical: 144-167
Cytoplasmic: 168-174
Helical: 175-194
Extracellular: 195-216
Helical: 217-240
Cytoplasmic: 241-254
Helical: 255-276
Extracellular: 277-294
Helical: 295-317
Cytoplasmic: 318-343
Helical: 344-362
Extracellular: 363-369
Helical: 370-392
Cytoplasmic: 393-440

PTM

Phosphorylated on Ser and Thr residues at the cytoplasmic C-terminus by G protein-coupled receptor kinases (GRKs).