Mouse Anti-SCTR Recombinant Antibody (CBXS-4935) (CBMAB-S2157-CQ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
Upon binding to secretin, regulates the pH of the duodenum by 1 inhibiting the secretion of gastric acid from the parietal cells of the stomach and 2 stimulating the production of bicarbonate (NaHCO3) from the ductal cells of the pancreas (By similarity).
In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity).
Biological Process brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell surface receptor signaling pathwayIEA:InterPro
Biological Process cellular water homeostasisISS:UniProtKB
Biological Process diet induced thermogenesisISS:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:GO_Central
Biological Process positive regulation of cAMP-mediated signalingISS:UniProtKB
Biological Process regulation of appetiteISS:UniProtKB
Biological Process regulation of synaptic plasticityISS:UniProtKB
Biological Process response to nutrient levelsISS:UniProtKB
Helical: 144-167
Cytoplasmic: 168-174
Helical: 175-194
Extracellular: 195-216
Helical: 217-240
Cytoplasmic: 241-254
Helical: 255-276
Extracellular: 277-294
Helical: 295-317
Cytoplasmic: 318-343
Helical: 344-362
Extracellular: 363-369
Helical: 370-392
Cytoplasmic: 393-440
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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