SCUBE2

Signal Peptide, CUB Domain And EGF Like Domain Containing 2

Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548).
Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195).
Synergizes with DISP1 to increase SHH secretion (PubMed:22902404).
Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).

Signal transduction

Secreted
Cell surface
Secreted and tethered at the cell surface (PubMed:19480626).

N-glycosylated.