Mouse Anti-SCUBE2 Recombinant Antibody (CBXS-2248) (CBMAB-S5010-CQ)

Name: Mouse Anti-SCUBE2 Recombinant Antibody (CBXS-2248)
SKU: CBMAB-S5010-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-2248

Application

WB, IP, IF, ELISA

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Signal Peptide, CUB Domain And EGF Like Domain Containing 2

Entrez Gene ID

57758

UniProt ID

Q9NQ36

Alternative Names

Signal Peptide, CUB Domain And EGF Like Domain Containing 2; Signal Peptide, CUB Domain, EGF-Like 2; Scube/You; CEGP1; Signal Peptide, CUB And EGF-Like Domain-Containing Protein 2; Protein CEGP1; CEGB1; CEGF1;

Function

Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548).
Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195).
Synergizes with DISP1 to increase SHH secretion (PubMed:22902404).
Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).

Biological Process

Signal transduction

Cellular Location

Secreted
Cell surface
Secreted and tethered at the cell surface (PubMed:19480626).

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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