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Mouse Anti-SCUBE2 Recombinant Antibody (CBXS-2248) (CBMAB-S5010-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2248
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Signal Peptide, CUB Domain And EGF Like Domain Containing 2
Entrez Gene ID
57758
UniProt ID
Q9NQ36
Alternative Names
Signal Peptide, CUB Domain And EGF Like Domain Containing 2; Signal Peptide, CUB Domain, EGF-Like 2; Scube/You; CEGP1; Signal Peptide, CUB And EGF-Like Domain-Containing Protein 2; Protein CEGP1; CEGB1; CEGF1;
Function
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548).
Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195).
Synergizes with DISP1 to increase SHH secretion (PubMed:22902404).
Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).
Biological Process
Signal transduction
Cellular Location
Secreted
Cell surface
Secreted and tethered at the cell surface (PubMed:19480626).
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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