SCXA

In August, 2010 the Genome Reference Consortium determined that the region contains a duplication error. The clone on which SCXA was based (AC110280.8) was be removed from the GRCh38 reference assembly and SCXB was retained and renamed to SCX.

Full Name

Scleraxis bHLH transcription factor

Function

Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.

Biological Process

Biological Process BMP signaling pathwayISS:UniProtKB
Biological Process cell differentiationISS:UniProtKB
Biological Process cellular response to mechanical stimulusIEA:Ensembl
Biological Process cellular response to transforming growth factor beta stimulusIEA:Ensembl
Biological Process chondrocyte differentiationISS:UniProtKB
Biological Process collagen fibril organizationISS:UniProtKB
Biological Process deltoid tuberosity developmentISS:UniProtKB
Biological Process developmental processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA-templated transcriptionISS:UniProtKB
Biological Process embryonic skeletal system developmentIEA:Ensembl
Biological Process endochondral ossificationISS:UniProtKB
Biological Process face morphogenesisIEA:Ensembl
Biological Process heart valve formationISS:UniProtKB
Biological Process heart valve morphogenesisISS:UniProtKB
Biological Process mesoderm formationISS:UniProtKB
Biological Process negative regulation of apoptotic processISS:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionIEA:Ensembl
Biological Process positive regulation of cartilage developmentISS:UniProtKB
Biological Process positive regulation of cell population proliferationISS:UniProtKB
Biological Process positive regulation of collagen biosynthetic processISS:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process positive regulation of gastrulationISS:UniProtKB
Biological Process positive regulation of gene expressionISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:GO_Central
Biological Process regulation of cartilage developmentISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sclerotome developmentIEA:Ensembl
Biological Process Sertoli cell differentiationISS:UniProtKB
Biological Process skeletal muscle cell differentiationIEA:Ensembl
Biological Process tendon cell differentiationISS:UniProtKB
Biological Process tendon developmentISS:UniProtKB
Biological Process tendon formationISS:UniProtKB
Biological Process tissue homeostasisISS:UniProtKB

Cellular Location

Nucleus