SEMA3F

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms.

Full Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

Function

May play a role in cell motility and cell adhesion.

Biological Process

Biological Process axon extension involved in axon guidanceISS:BHF-UCL
Biological Process axon guidanceManual Assertion Based On ExperimentIDA:MGI
Biological Process branchiomotor neuron axon guidanceIEA:Ensembl
Biological Process facial nerve structural organizationIEA:Ensembl
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process nerve developmentISS:BHF-UCL
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migration involved in autonomic nervous system developmentIEA:Ensembl
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of postsynapse organizationIEA:Ensembl
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathway involved in axon guidanceIEA:Ensembl
Biological Process semaphorin-plexin signaling pathway involved in neuron projection guidanceISS:BHF-UCL
Biological Process sympathetic ganglion developmentISS:BHF-UCL
Biological Process sympathetic neuron projection extensionISS:BHF-UCL
Biological Process sympathetic neuron projection guidanceISS:BHF-UCL
Biological Process trigeminal nerve structural organizationIEA:Ensembl
Biological Process ventral trunk neural crest cell migrationIEA:Ensembl

Cellular Location

Secreted