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SEMA4D

SEMA4D (Semaphorin 4D) is a Protein Coding gene. Diseases associated with SEMA4D include Hemorrhagic Fever With Renal Syndrome and Osteonecrosis Of The Jaw. Among its related pathways are Development Slit-Robo signaling and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include receptor binding and transmembrane signaling receptor activity. An important paralog of this gene is SEMA4C.
Full Name
Semaphorin 4D
Function
Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282).
Regulates GABAergic synapse development (By similarity).
Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity).
Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569).
Promotes the migration of cerebellar granule cells (PubMed:16055703).
Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214).
Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).
Biological Process
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte aggregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of alkaline phosphatase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of osteoblast differentiationISS:BHF-UCL
Biological Process negative regulation of peptidyl-tyrosine phosphorylationISS:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ossification involved in bone maturationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of collateral sproutingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of inhibitory synapse assemblyISS:UniProtKB
Biological Process positive regulation of peptidyl-tyrosine phosphorylationISS:BHF-UCL
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cell projection organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of dendrite morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process semaphorin-plexin signaling pathway involved in bone trabecula morphogenesisISS:BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 22-734
Helical: 735-755
Cytoplasmic: 756-862

Anti-SEMA4D antibodies

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Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-3024
Application*: E, WB
Target: SEMA4D
Host: Rat
Specificity: Mouse
Clone: CBXS-2622
Application*: WB
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1929
Application*: IC
Target: SEMA4D
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-1855
Application*: WB
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SEMA4D/933
Application*: F, IF
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 133-1C6
Application*: F, E, IP
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: A8
Application*: F
Target: SEMA4D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0058
Application*: IC, P, WB
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-4432
Application*: E, F, IP
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: M188
Application*: WB, E, IC
Target: SEMA4D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1205
Application*: WB, P, IC
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1135
Application*: F
Target: SEMA4D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-1061
Application*: ED
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXS-0206
Application*: F, C, IP
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0205
Application*: F, IP, WB
Target: SEMA4D
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-C1157
Application*: F
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1158
Application*: E
Target: SEMA4D
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXS-0204
Application*: E, WB
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0203
Application*: E, WB
Target: SEMA4D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: E8S8A
Application*: WB, IP
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C4D204
Application*: P
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-3106
Application*: F, IP
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3107
Application*: E
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBFYC-3108
Application*: IP
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Baboon
Clone: CBFYC-3109
Application*: F, IF
Target: SEMA4D
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-0806
Application*: F
Target: SEMA4D
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXS-1856
Application*: F
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1928
Application*: F
Target: SEMA4D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-1077
Application*: F, IF, IF
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5935
Application*: WB, IH
Target: SEMA4D
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-3668
Application*: EC
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5282
Application*: WB, IH
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 30/CD100
Application*: WB, IF, IH
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1794
Application*: F, IP, WB
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 11E116
Application*: F, IP
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 133.1G6
Application*: IP
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2
Application*: E
Target: SEMA4D
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 547412
Application*: F
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6
Application*: E
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 7H103
Application*: F
Target: SEMA4D
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MMA-12
Application*: F
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B4
Application*: WB, E
Target: SEMA4D
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF386
Application*: ELISA, WB, IHC
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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