Mouse Recombinant SEMA4D protein, ECD, His Tag-1 (V2LY-0526-LY8876)

Semaphorin 4D

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282).
Regulates GABAergic synapse development (By similarity).
Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity).
Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569).
Promotes the migration of cerebellar granule cells (PubMed:16055703).
Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214).
Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).

Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process immune responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process leukocyte aggregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of alkaline phosphatase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of osteoblast differentiationISS:BHF-UCL
Biological Process negative regulation of peptidyl-tyrosine phosphorylationISS:BHF-UCL
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ossification involved in bone maturationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of collateral sproutingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of inhibitory synapse assemblyISS:UniProtKB
Biological Process positive regulation of peptidyl-tyrosine phosphorylationISS:BHF-UCL
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cell projection organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of dendrite morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process semaphorin-plexin signaling pathway involved in bone trabecula morphogenesisISS:BHF-UCL

Cell membrane

Extracellular: 22-734
Helical: 735-755
Cytoplasmic: 756-862