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SEMA6C

This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration.

Full Name

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

Function

Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.

Biological Process

Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extensionIDA:UniProtKB
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 25-604
Helical: 605-625
Cytoplasmic: 626-930

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Anti-SEMA6C antibodies

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Rat Anti-SEMA6C Recombinant Antibody (CBXS-5708) (CBMAB-S0576-CQ)

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Target: SEMA6C

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXS-5708

Application*: IH, WB

Human SEMA6C ELISA Kit (V2LY-0626-LY1124)

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Target: SEMA6C

Sensitivity: 0.0082 ng/mL

Detection Range: 0.015-3 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Rat Anti-SEMA6C Recombinant Antibody (CBXS-2558) (CBMAB-S5314-CQ)

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Target: SEMA6C

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXS-2558

Application*: IH, WB

Mouse Anti-SEMA6C Recombinant Antibody (CBXS-2557) (CBMAB-S5313-CQ)

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Target: SEMA6C

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXS-2557

Application*: WB

Rat Anti-SEMA6C Recombinant Antibody (CBXS-1740) (CBMAB-S4566-CQ)

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Target: SEMA6C

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXS-1740

Application*: WB, IH

Mouse Anti-SEMA6C Recombinant Antibody (CBXS-1736) (CBMAB-S4562-CQ)

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Target: SEMA6C

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-1736

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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