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SEPT11

SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM

Full Name

septin 11

Function

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).
During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.

Biological Process

Biological Process cytoskeleton-dependent cytokinesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein localizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytoskeleton
Synapse
Cell projection, dendritic spine
Cell projection, axon
Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.

Involvement in disease

A chromosomal aberration involving SEPTIN11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.

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Anti-SEPT11 antibodies

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Mouse Anti-SEPT11 Recombinant Antibody (1E5) (CBMAB-C4270-CN)

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Target: SEPT11

Host: Mouse

Antibody Isotype: IgG2b, λ

Specificity: Human

Clone: 1E5

Application*: E, WB

Mouse Anti-SEPT11 Recombinant Antibody (CBXS-2763) (CBMAB-S5514-CQ)

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Target: SEPT11

Host: Mouse

Antibody Isotype: IgG2b, λ

Specificity: Human

Clone: CBXS-2763

Application*: E, WB

Mouse Anti-SEPT11 (N-Term) Recombinant Antibody (CBXS-0213) (CBMAB-S3196-CQ)

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Target: SEPT11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-0213

Application*: WB

Mouse Anti-SEPT11 Recombinant Antibody (CBXS-5954) (CBMAB-S0801-CQ)

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Target: SEPT11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5954

Application*: DB, IC, WB

Mouse Anti-SEPT11 Recombinant Antibody (998C6a) (CBMAB-0818CQ)

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Target: SEPT11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 998C6a

Application*: WB, DB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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