SEPT11

SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM

Full Name

septin 11

Function

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).
During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.

Biological Process

Biological Process cytoskeleton-dependent cytokinesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein localizationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytoskeleton
Synapse
Cell projection, dendritic spine
Cell projection, axon
Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.

Involvement in disease

A chromosomal aberration involving SEPTIN11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.

Anti-SEPT11 antibodies

Mouse Anti-SEPT11 Recombinant Antibody (CBXS-5954) (CBMAB-S0801-CQ)

Datasheet

SDS

Target: SEPT11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5954

Application*: DB, IC, WB

Mouse Anti-SEPT11 (N-Term) Recombinant Antibody (CBXS-0213) (CBMAB-S3196-CQ)

Datasheet

SDS

Target: SEPT11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-0213

Application*: WB

Mouse Anti-SEPT11 Recombinant Antibody (CBXS-2763) (CBMAB-S5514-CQ)

Datasheet

SDS

Target: SEPT11

Host: Mouse

Antibody Isotype: IgG2b, λ

Specificity: Human

Clone: CBXS-2763

Application*: E, WB

Mouse Anti-SEPT11 Recombinant Antibody (1E5) (CBMAB-C4270-CN)

Datasheet

SDS

Target: SEPT11

Host: Mouse

Antibody Isotype: IgG2b, λ

Specificity: Human

Clone: 1E5

Application*: E, WB

Mouse Anti-SEPT11 Recombinant Antibody (998C6a) (CBMAB-0818CQ)

Datasheet

SDS

Target: SEPT11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 998C6a

Application*: WB, DB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)