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Mouse Anti-SEPT11 Recombinant Antibody (998C6a) (CBMAB-0818CQ)

This product is a mouse antibody that recognizes SEPT11. The antibody 998C6a can be used for immunoassay techniques such as: WB, Dot.
See all SEPT11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
998C6a
Antibody Isotype
IgG1
Application
WB, Dot

Basic Information

Immunogen
Recombinant fragment corresponsing to a region close to the N-terminus of Human Septin 11
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
septin 11
Introduction
SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking.Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity. During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.
Entrez Gene ID
55752
UniProt ID
Q9NVA2
Alternative Names
septin 11
Function
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).
During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.
Biological Process
Biological Process cytoskeleton-dependent cytokinesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein localizationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton
Synapse
Cell projection, dendritic spine
Cell projection, axon
Partly colocalizes with stress fibers and microtubules. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
Involvement in disease
A chromosomal aberration involving SEPTIN11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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