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SFMBT1

This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]

Full Name

Scm Like With Four Mbt Domains 1

Function

Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.

Biological Process

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of muscle organ developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process spermatogenesisIEA:UniProtKB-KW

Cellular Location

Nucleus

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Anti-SFMBT1 antibodies

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Mouse Anti-SFMBT1 Monoclonal Antibody (2C1) (CBMAB-0093-LY)

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Target: SFMBT1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2C1

Application*: IP, M

SFMBT1 Matched Antibody Pair (1075) (APMAB-1075LY)

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Target: SFMBT1

Specificity: Human

Mouse Anti-SFMBT1 Recombinant Antibody (2A1) (CBMAB-A8025-LY)

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Target: SFMBT1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2A1

Application*: WB, E

Mouse Anti-SFMBT1 Recombinant Antibody (CBXS-0294) (CBMAB-S3269-CQ)

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Target: SFMBT1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-0294

Application*: IP

Mouse Anti-SFMBT1 Recombinant Antibody (CBXS-4321) (CBMAB-S1566-CQ)

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Target: SFMBT1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-4321

Application*: WB, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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