SGCB

This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy
Full Name
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Function
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Biological Process
Biological Process cardiac muscle cell developmentIEA:Ensembl
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process vascular associated smooth muscle cell developmentIEA:Ensembl
Cellular Location
Cell membrane, sarcolemma
Cytoplasm, cytoskeleton
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal recessive 4 (LGMDR4):
An autosomal recessive degenerative myopathy characterized by pelvic and shoulder muscle wasting, onset usually in childhood and variable progression rate.
Topology
Cytoplasmic: 1-65
Helical: 66-86
Extracellular: 87-318
PTM
Disulfide bonds are present.
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Anti-SGCB antibodies

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Mouse Anti-SGCB Recombinant Antibody (1C10) (CBMAB-A8053-LY)

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Target: SGCB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C10
Application*: WB, E
Datasheet SDS

Mouse Anti-SGCB Recombinant Antibody (1E3) (CBMAB-A8052-LY)

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Target: SGCB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E3
Application*: WB, E
Datasheet SDS

Mouse Anti-SGCB Recombinant Antibody (CBXS-0946) (CBMAB-S3859-CQ)

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Target: SGCB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0946
Application*: E, WB, IF, P
Datasheet SDS

Mouse Anti-SGCB Recombinant Antibody (CBXS-4053) (CBMAB-S1312-CQ)

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Target: SGCB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-4053
Application*: E, WB, C
Datasheet SDS

Mouse Anti-SGCB Recombinant Antibody (CBXS-3898) (CBMAB-S1167-CQ)

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Target: SGCB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-3898
Application*: E, WB, P, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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