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SGCB

This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy

Full Name

sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Biological Process

Biological Process cardiac muscle cell developmentIEA:Ensembl
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process vascular associated smooth muscle cell developmentIEA:Ensembl

Cellular Location

Cell membrane, sarcolemma
Cytoplasm, cytoskeleton

Involvement in disease

Muscular dystrophy, limb-girdle, autosomal recessive 4 (LGMDR4):
An autosomal recessive degenerative myopathy characterized by pelvic and shoulder muscle wasting, onset usually in childhood and variable progression rate.

Topology

Cytoplasmic: 1-65
Helical: 66-86
Extracellular: 87-318

PTM

Disulfide bonds are present.

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Anti-SGCB antibodies

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Mouse Anti-SGCB Recombinant Antibody (1C10) (CBMAB-A8053-LY)

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Target: SGCB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1C10

Application*: WB, E

Mouse Anti-SGCB Recombinant Antibody (1E3) (CBMAB-A8052-LY)

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Target: SGCB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1E3

Application*: WB, E

Mouse Anti-SGCB Recombinant Antibody (CBXS-0946) (CBMAB-S3859-CQ)

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Target: SGCB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-0946

Application*: E, WB, IF, P

Mouse Anti-SGCB Recombinant Antibody (CBXS-4053) (CBMAB-S1312-CQ)

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Target: SGCB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-4053

Application*: E, WB, C

Mouse Anti-SGCB Recombinant Antibody (CBXS-3898) (CBMAB-S1167-CQ)

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Target: SGCB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3898

Application*: E, WB, P, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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