SGCB

This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy

Full Name

sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Biological Process

Biological Process cardiac muscle cell developmentIEA:Ensembl
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process vascular associated smooth muscle cell developmentIEA:Ensembl

Cellular Location

Cell membrane, sarcolemma
Cytoplasm, cytoskeleton

Involvement in disease

Muscular dystrophy, limb-girdle, autosomal recessive 4 (LGMDR4):
An autosomal recessive degenerative myopathy characterized by pelvic and shoulder muscle wasting, onset usually in childhood and variable progression rate.

Topology

Cytoplasmic: 1-65
Helical: 66-86
Extracellular: 87-318

PTM

Disulfide bonds are present.

Anti-SGCB antibodies

Mouse Anti-SGCB Recombinant Antibody (CBXS-3898) (CBMAB-S1167-CQ)

Datasheet

SDS

Target: SGCB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3898

Application*: E, WB, P, IF

Mouse Anti-SGCB Recombinant Antibody (CBXS-4053) (CBMAB-S1312-CQ)

Datasheet

SDS

Target: SGCB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXS-4053

Application*: E, WB, C

Mouse Anti-SGCB Recombinant Antibody (CBXS-0946) (CBMAB-S3859-CQ)

Datasheet

SDS

Target: SGCB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-0946

Application*: E, WB, IF, P

Mouse Anti-SGCB Recombinant Antibody (1E3) (CBMAB-A8052-LY)

Datasheet

SDS

Target: SGCB

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1E3

Application*: WB, E

Mouse Anti-SGCB Recombinant Antibody (1C10) (CBMAB-A8053-LY)

Datasheet

SDS

Target: SGCB

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1C10

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)