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Mouse Anti-SGCB Recombinant Antibody (1E3) (CBMAB-A8052-LY)

The product is antibody recognizes SGCB. The antibody 1E3 immunoassay techniques such as: WB, ELISA.
See all SGCB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E3
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
SGCB (AAH20709, 1 a.a. ~ 318 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
Introduction
This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy
Entrez Gene ID
6443
UniProt ID
Q16585
Alternative Names
A3b; LGMD2E; SGC
Function
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Biological Process
Biological Process cardiac muscle cell developmentIEA:Ensembl
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process vascular associated smooth muscle cell developmentIEA:Ensembl
Cellular Location
Cell membrane, sarcolemma
Cytoplasm, cytoskeleton
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal recessive 4 (LGMDR4):
An autosomal recessive degenerative myopathy characterized by pelvic and shoulder muscle wasting, onset usually in childhood and variable progression rate.
Topology
Cytoplasmic: 1-65
Helical: 66-86
Extracellular: 87-318
PTM
Disulfide bonds are present.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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