Mouse Anti-SGCB Recombinant Antibody (1C10) (CBMAB-A8053-LY)

Name: Mouse Anti-SGCB Recombinant Antibody (1C10)
SKU: CBMAB-A8053-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1C10

Application

WB, ELISA

Immunogen

SGCB (NP_000223, 87 a.a. ~ 196 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)

Introduction

This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy

Entrez Gene ID

6443

UniProt ID

Q16585

Alternative Names

A3b; LGMD2E; SGC

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Biological Process

Biological Process cardiac muscle cell developmentIEA:Ensembl
Biological Process muscle organ developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process vascular associated smooth muscle cell developmentIEA:Ensembl

Cellular Location

Cell membrane, sarcolemma
Cytoplasm, cytoskeleton

Involvement in disease

Muscular dystrophy, limb-girdle, autosomal recessive 4 (LGMDR4):
An autosomal recessive degenerative myopathy characterized by pelvic and shoulder muscle wasting, onset usually in childhood and variable progression rate.

Topology

Cytoplasmic: 1-65
Helical: 66-86
Extracellular: 87-318

PTM

Disulfide bonds are present.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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