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SIGLEC6

This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

Full Name

Sialic Acid Binding Ig Like Lectin 6

Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Biological Process

Biological Process cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Isoform 1
Cell membrane
Isoform 2
Secreted

Topology

Extracellular: 27-347
Helical: 348-368
Cytoplasmic: 369-453

Anti-SIGLEC6 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-SIGLEC6 Recombinant Antibody (2G6) (CBMAB-A8124-LY)

SDS

Target: SIGLEC6

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2G6

Application*: WB, E

SIGLEC6 Matched Antibody Pair (1095) (APMAB-1095LY)

SDS

Target: SIGLEC6

Specificity: Human

Mouse Anti-SIGLEC6 Recombinant Antibody (CBXS-2950) (CBMAB-S5699-CQ)

SDS

Target: SIGLEC6

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-2950

Application*: E, IP, WB

Mouse Anti-SIGLEC6 Recombinant Antibody (CBXS-1933) (CBMAB-S0141-CQ)

SDS

Target: SIGLEC6

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-1933

Application*: F

Human Anti-SIGLEC6 Recombinant Antibody (CBXC-0931) (CBMAB-C2047-CQ)

SDS

Target: SIGLEC6

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0931

Application*: F

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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