SIX2

This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq]

Full Name

SIX homeobox 2

Function

Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. May also be involved in limb tendon and ligament development (By similarity).
Plays a role in cell proliferation and migration.

Biological Process

Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Biological Process anterior/posterior axis specificationISS:UniProtKB
Biological Process cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process chondrocyte differentiationIEA:Ensembl
Biological Process condensed mesenchymal cell proliferationIEA:Ensembl
Biological Process embryonic cranial skeleton morphogenesisIEA:Ensembl
Biological Process embryonic digestive tract morphogenesisISS:UniProtKB
Biological Process kidney developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mesenchymal cell differentiation involved in kidney developmentISS:UniProtKB
Biological Process mesenchymal stem cell maintenance involved in nephron morphogenesisISS:UniProtKB
Biological Process mesenchymal stem cell proliferationISS:UniProtKB
Biological Process mesenchymal to epithelial transition involved in metanephros morphogenesisISS:UniProtKB
Biological Process mesodermal cell fate specificationISS:UniProtKB
Biological Process middle ear morphogenesisIEA:Ensembl
Biological Process negative regulation of epithelial cell differentiationIEA:Ensembl
Biological Process nephron developmentISS:UniProtKB
Biological Process nephron morphogenesisISS:UniProtKB
Biological Process positive regulation of chondrocyte proliferationISS:UniProtKB
Biological Process protein import into nucleusIEA:Ensembl
Biological Process regulation of branching involved in ureteric bud morphogenesisISS:UniProtKB
Biological Process regulation of chondrocyte differentiationIEA:Ensembl
Biological Process regulation of ossificationIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus