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SLAMF1

SLAMF1 (Signaling Lymphocytic Activation Molecule Family Member 1) is a Protein Coding gene. Diseases associated with SLAMF1 include Measles and Lymphoproliferative Syndrome, X-Linked, 1. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Dendritic Cells Developmental Lineage Pathway. Gene Ontology (GO) annotations related to this gene include antigen binding.
Full Name
Signaling Lymphocytic Activation Molecule Family Member 1
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999).
However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214).
Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity).
Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity).
Promotes T-cell receptor-induced IL-4 secretion by CD4+ cells (By similarity).
Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4-/CD8- T-cells (By similarity).
Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity).
May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102).
May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity).
In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity).
In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity).
In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity).
In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852).
In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity).
Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns3P and NOX2 activity in the phagosomes (PubMed:20818396).
(Microbial infection) Acts as a receptor for Measles virus; also including isoform 4.
Biological Process
Biological Process adaptive immune responseIEA:UniProtKB-KW
Biological Process cell adhesionIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process leukocyte chemotaxis involved in inflammatory responseIEA:Ensembl
Biological Process myeloid dendritic cell activation involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process natural killer cell differentiationIEA:Ensembl
Biological Process natural killer cell proliferationIEA:Ensembl
Biological Process negative regulation of CD40 signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of interferon-gamma productionIEA:Ensembl
Biological Process negative regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of T cell cytokine productionIEA:Ensembl
Biological Process negative regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phagocytosisIEA:UniProtKB-KW
Biological Process positive regulation of activated T cell proliferationIEA:Ensembl
Biological Process positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of dendritic cell chemotaxisIEA:Ensembl
Biological Process positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of macrophage chemotaxisIEA:Ensembl
Biological Process positive regulation of T-helper 1 cell cytokine productionIEA:Ensembl
Biological Process regulation of catalytic activityIEA:Ensembl
Biological Process regulation of vesicle fusionIEA:Ensembl
Cellular Location
Cell membrane
Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999).
Isoform 3
Secreted
Isoform 4
Cell membrane
Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers.
Topology
Extracellular: 21-237
Helical: 238-258
Cytoplasmic: 259-335
PTM
Phosphorylated on tyrosine residues by FYN.

Anti-SLAMF1 antibodies

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Target: SLAMF1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXS-0420
Application*: F, FN
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-0418
Application*: E, F, IC, WB
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4441
Application*: E, F, IH, IP
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SHM-57
Application*: F, IC, IF, C, IP
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IPO-3
Application*: E
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-1666
Application*: WB
Target: SLAMF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1531
Application*: WB, IP
Target: SLAMF1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYC-0190
Application*: F
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3116
Application*: F, IC, IF, IH
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-3117
Application*: E, WB
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3118
Application*: E
Target: SLAMF1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0720
Application*: F
Target: SLAMF1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXS-1831
Application*: F
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1852
Application*: F
Target: SLAMF1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 9D1
Application*: F
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXS-5732
Application*: E, WB
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXS-5843
Application*: WB
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-6096
Application*: F, FN, IP
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1V004
Application*: E, WB
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 02
Application*: ED
Target: SLAMF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 11E1
Application*: EC
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4j33
Application*: F, IP
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11E118
Application*: F, IC, IF, IH
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6D304
Application*: E, F, C, WB
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0290
Application*: F, IP
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2128
Application*: E, F, IC, WB
Target: SLAMF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2129
Application*: E, P
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A12
Application*: FC, IP
Target: SLAMF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9H94
Application*: FC, WB
Target: SLAMF1
Host: Rat
Antibody Isotype: IgG2a, λ
Specificity: Mouse
Clone: TC15-12F12.2
Application*: F
Target: SLAMF1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: mShad150
Application*: F
Target: SLAMF1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CF396
Application*: FC
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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