SLAMF8

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes.

SLAM Family Member 8

May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

Biological Process B-1 B cell lineage commitmentBy SimilarityISS:UniProtKB
Biological Process defense response to bacteriumISS:UniProtKB
Biological Process leukocyte chemotaxis involved in inflammatory responseISS:UniProtKB
Biological Process negative regulation of dendritic cell chemotaxisISS:UniProtKB
Biological Process negative regulation of macrophage chemotaxisISS:UniProtKB
Biological Process negative regulation of monocyte chemotaxisISS:UniProtKB
Biological Process negative regulation of neutrophil migrationISS:UniProtKB
Biological Process negative regulation of respiratory burst involved in inflammatory responseISS:UniProtKB
Biological Process phagosome acidificationISS:UniProtKB
Biological Process regulation of B cell differentiationBy SimilarityISS:UniProtKB
Biological Process regulation of kinase activityISS:UniProtKB
Biological Process regulation of NAD(P)H oxidase activityISS:UniProtKB

Membrane

Extracellular: 23-233
Helical: 234-254
Cytoplasmic: 255-285