SLC15A1

This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.

Full Name

solute carrier family 15 (oligopeptide transporter), member 1

Function

Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:7896779, PubMed:18367661, PubMed:19685173).
Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity).

Biological Process

Biological Process dipeptide import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ion transportTAS:Reactome
Biological Process protein transportIEA:UniProtKB-KW
Biological Process tripeptide import across plasma membraneISS:ARUK-UCL

Cellular Location

Membrane

Topology

Helical: 1-21
Extracellular: 22-53
Helical: 54-74
Cytoplasmic: 75-82
Helical: 83-103
Extracellular: 104-118
Helical: 119-139
Cytoplasmic: 140-161
Helical: 162-182
Extracellular: 183-198
Helical: 199-219
Cytoplasmic: 220-276
Helical: 277-297
Extracellular: 298-327
Helical: 328-348
Cytoplasmic: 349-361
Helical: 362-382
Extracellular: 383-584
Helical: 585-605
Cytoplasmic: 606-619
Helical: 620-640
Extracellular: 641-645
Helical: 646-666
Cytoplasmic: 667-708