SLC38A2

Full Name

Solute Carrier Family 38 Member 2

Function

Symporter that cotransports neutral amino acids and sodium ions from the extraccellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15922329, PubMed:16621798, PubMed:15774260).
The trasnport is pH-sensitive, Li+-intolerant, electrogenic, driven by the Na+ electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (PubMed:10930503, PubMed:15774260).
May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity).
Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity).
Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity).

Biological Process

Biological Process alanine transportISS:UniProtKB
Biological Process amino acid importISS:UniProtKB
Biological Process amino acid transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process amino acid transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to amino acid starvationIEA:Ensembl
Biological Process cellular response to arsenite(3-)Manual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process cellular response to mechanical stimulusIEA:Ensembl
Biological Process cerebral cortex developmentIEA:Ensembl
Biological Process female pregnancyIEA:Ensembl
Biological Process glutamine transportISS:ARUK-UCL
Biological Process glycine betaine transportIEA:Ensembl
Biological Process L-glutamine import across plasma membraneISS:UniProtKB
Biological Process L-proline import across plasma membraneISS:UniProtKB
Biological Process L-serine import across plasma membraneISS:UniProtKB
Biological Process L-serine transportISS:ARUK-UCL
Biological Process neurotransmitter transportTAS:Reactome
Biological Process neutral amino acid transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIPI:ARUK-UCL
Biological Process positive regulation of RNA splicingManual Assertion Based On ExperimentIPI:ARUK-UCL
Biological Process proline transportISS:UniProtKB
Biological Process regulation of cellular response to stressManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of glutamate secretion, neurotransmissionISS:UniProtKB
Biological Process response to muscle activityIEA:Ensembl
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL

Cellular Location

Cell membrane
Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal.

PTM

Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2.